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GRAVITATIONAL PHARMACOLOGY OF DRUGS AFFECTING RENIN-ANGIOTENSIN-ALDOSTERONE



Ye.N. Zaitseva
A.V. Dubishchev
13zen31@mail.ru
13zen31@mail.ru
senior lecturer, the Department of Pharmacology, prof. Lebedev Samara State Medical University, Doctor of Medicine
Head of the Department of Pharmacology, prof. Lebedev Samara State Medical University, Doctor of Medicine, professor
Samara
Samara

Keywords:

  • kidneys
  • excretory renal function
  • angiotensin-converting enzyme inhibitor captopril
  • angiotensin receptor blocker losartan
  • gravitational action
  • gravitational therapy
  • It has been discovered during experiments on white rats that the pharmacological agents affecting the renin-angiotensin-aldosterone system under gravitational impact can significantly change their influence on the excretory function of the kidneys. The inhibitor of the angiotensin-converting enzyme captopril under single intragastric administration of an effective average therapeutic dose of 7 mg/kg contributes to the delayed isolated growth of potassiumuresis. However, against the background of gravitational action +3g directed to the kidneys of the animal it contributes to a significantly delayed growth of diuresis and natriuresis, similar to hypothiazide of 20 mg/kg under normal gravity. In its turn, the same dose of angiotensin receptor blocker losartan under normal gravity conditions contributes to accelerated and delayed growth of potassiumuresis, and in combination with the above-mentioned gravitational action to a delayed significant increase in diuresis, saluresis and creatininuresis, similar to hypothiazide in hypergravity.