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Modern Ideas of Cell Death Mechanisms



V.S. Novikov
E.B. Shustov
raen.vsn@mail.ru
shustov-msk@mail.ru
Vice President of the Russian Academy of Natural Sciences, chairperson of section of Interdisciplinary problems of science and education of the Russian Academy of Natural Sciences, member of Russian Academy of Natural Sciences, Honored Science Worker, Laureate of the State Prize of the Russian Federation in Science and Engineering, Doctor of Medicine, professor
leading researcher, the S.N. Golikov Toxicology Research center, the Federal Medical-Biological Agency, professor of the Department of Pharmacology and Clinical Pharmacology, St. Petersburg State Chemical-Pharmaceutical University of the Ministry of Healthcare, member of the Russian Academy of Natural Sciences, Laureate of the State Prize of the Russian Federation in Science and Engineering, Doctor of Medicine, professor
St. Petersburg
St. Petersburg

Keywords:

  • apoptosis
  • anastasis
  • necrosis
  • cell death
  • cytoprotection
  • induction of cancer cell death
  • molecular biology
  • We present a literature review reflecting the main modern concepts of cell death as an important element of the cell life cycle, its types, patterns and mechanisms of its course, and its role in the pathogenesis of various diseases. We demonstrate the potential of studying the mechanisms of cell death from the point of view of organism ageing and protection of cells from various damages; the development of innovative medical technologies for the treatment of a wide range of diseases is described. New directions in the study of cell death reflect the trends in the development of molecular biology and pharmacology in such areas as cytoprotection, oncology, and reparative medicine. We provide the data concerning the reversibility at a certain stage of changes caused by the induction of apoptosis in cell culture which characterizes a special process known as anastase as a mechanism for restoring the functional activity and structure of cells at early stages of programmed cell death caused by inducing impact.